Endocrine Abstracts

Primary hypophysitis (PH) is a rare clinical entity usually presenting with headaches, pituitary deficiency, visual field defects and exceptionally with symptoms of cavernous sinus infiltration such as cranial nerve palsies. An internal carotid artery (ICA) occlusion is unusual complication of PH infiltrating the cavernous sinus. A 32-year old woman presented with a 4-year history of recurring headaches, right retro-orbital pain, periodic diplopia and secondary adren...

Introduction: Pregnancy in an acromegalic woman is rare and generally safe, but tumor expansion may occur. As this is a rare occurrence, little is known about the optimum management of such patients during pregnancy. We present the case of a woman with acromegaly treated with Lanreotide during pregnancyCase report: A 29-year-old woman with acromegaly underwent transsphenoidal resection of invasive pituitary macroadenoma in August 2014, without cure. In N...

Background: Primary aldosteronism (PA) is the most frequent cause of hormonal hypertension, typically associated with hypokalaemia. Whereas hypertension with no hypokalaemia can be present in even half of cases, hypokaleamia in normotensive patients is a very rare finding. Mechanisms that act against developing hypertension despite aldosterone excess are at least a few. Some patients with previous low blood pressure increase its values because of hyperaldosteronism, thus still...

Introduction: The treatment of choice in persistent acromegaly after transsphenoidal adenomectomy is pharmacological treatment with first generation somatostatin analogs. They are effective in 25% to 45% of patients. Second generation somatostatin analog – pasireotide seems to be more effective.Aim: The aim of the study was to assess the efficacy and safety of pasireotide LAR in acromegaly patients resistant to first generation somatostatin analogs...

Introduction: Pheochromocytomas are rare neuroendocrine tumors arising from chromaffin cells of the adrenal medulla. Approximately 10% of all pheochromocytomas are malignant. There is no effective therapy for malignant pheochromocytoma (MAL-PHEO) and the overall prognosis is poor.Case report: We report 22-year survival with MAL-PHEO in a patient treated with several surgeries, 131I-metaiodobenzylguanidine and, subsequently, with long-acting fo...

Introduction: Clinically inapparent adrenal masses (incidentalomas) are detected incidentally by imaging procedures in 0.5–4.5% of the general population. Diagnostic process identifies functional and potentially malignant tumors. Adrenocortical tumors might be the first manifestation of non-classic congenital adrenal hyperplasia (NC-CAH). P30L, V281L and P453S mutations of CYP21 gene are the most common mutations of NC-CAH. The aim of the study was to evaluate the relatio...

Introduction: There is only few data on metabolic syndrome occurrence in young patients with childhood-onset GH deficiency (CO-GHD), especially its partial form.Aim: The aim of this study was the assessment of the metabolic syndrome criteria (according to IDF 2007) occurrence in adolescents and young adults with CO-GHD and evaluation of their correlations with the degree of GH/IGF-1 axis function impairment.Subjects and methods: Th...

A counter-regulatory rise in GC levels is important to the inflammatory response, that when impaired is associated with high mortality in inflammatory states. 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) regenerate’s intracellular glucocorticoids (GC), amplifying their actions, and has been postulated to play a role in the development of inflammation-associated arthritis, obesity and myopathy. Pro-inflammatory cytokines (e.g. TNF-α) increase expressio...

In this study, we attempted to demonstrate the expression of GHSR-1a receptor and possible effects of its activation in human, rat and boar spermatozoa. For demonstration of GHSR-1a immunocytochemical, immunofluorescence and western blotting techniques were applied. The effects of receptor activation was tested in a series of in vitro incubations of spermatozoa with or without addition of ghrelin and the effects were evaluated using confocal microscopy and flow cytometr...

Type 1 deiodinase (D1) catalyses deiodination of tyroxine (T4), which leads either to synthesis of triiodothyronine or reverse triiodothyronine (rT3). Triiodothyronine (T3) regulates the expression of many tumour suppressor genes and oncogenes. We previously revealed that the expression of the whole pool of D1 transcripts was dramatically lowered in ccRCC tissues. One of the mechanism resulting in this aberration could be miRNA-mediated repress...